Este fenómeno es conocido como efecto Jod-Basedow. El tratamiento con propiltiouracilo en dosis decrecientes consiguió un estado eutiroideo y mejoró la . Efectos de las hormomas tiroideas en el corazón. Visits . por el efecto de Wolff- Chaikoff, además de hipertiroidismo (mediado por el efecto de Jod-Basedow. de hipertiroidismo (mediado por el efecto de Jod-Basedow. En ambos casos, la causa subyacente es por la alta concentración de yodo en este medicamento.

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Consequently, thyroid hormone deficiencies, as well as excesses, are expected to result in profound changes in cardiac function regulation and cardiovascular hemodynamics. La exposici a cantidades excesivas de yodo bloquea la actividad de la enzima peroxidasa tiroidea TPOun feneno conocido como efecto de Wolff-Chaikoff.

Subclinical thyroid dysfunctions are independent risk factors for mortality in a 7. Longo, Joseph Loscalzo Harrison’s Principles of Internal Medicine.

Wolff–Chaikoff effect – Wikipedia

On the other hand, when thyrocites have low iodine levels and are exposed to a high iodine concentration, they increase significantly their production of thyroid hormone thus leading to hyperthyroidism, a phenomenon known as Jod-Basedow effect. Fortschr Geb Rontgenstrahlen Nuklearmed Ergan- zugsbd ; Thyroid function after hysterosalpingography using an oil-soluble iodinated contrast medium.

The Wolff—Chaikoff effect is an effective means of rejecting a large quantity of imbibed iodide, and therefore preventing the thyroid from synthesizing large quantities of thyroid hormone.

This page was last edited on 7 Augustat This phenomenon is thus iodine-induced hyperthyroidismtypically presenting in a patient with endemic goiter due to iodine deficiencywho relocate to an iodine-abundant geographical area. In some ways the Jod-Basedow phenomenon is the opposite of the Wolff—Chaikoff effectwhich refers to the short period of thyroid-hormone suppression which happens in normal persons and efectto persons with thyroid disease, when comparatively large quantities of iodine or iodide are ingested.


This page was last edited on 10 Augustat In Preedy, Victor R. The Wolff—Chaikoff effect is also part of the mechanism for the use of potassium iodide in nuclear emergencies.

However, unlike the Wolff-Chaikoff effectthe Jod-Basedow effect does not occur in persons with normal thyroid glands, as thyroid hormone synthesis and release in normal persons is controlled by pituitary TSH secretion which does not allow hyperthyroidism when extra iodine is ingested.

Overall, hyperthyroidism is characterized by an increase in resting heart rate, blood volume, stroke volume, myocardial contractility, and ejection fraction. Mico Magister en Epidemiolog Clica. Clinically, this effect can ffecto to hypothyroidism. Hypothalamic—pituitary—thyroid axis Hypothalamic—pituitary—adrenal iod Hypothalamic—pituitary—gonadal axis Hypothalamic—pituitary—somatotropic axis Hypothalamic—pituitary—prolactin axis Hypothalamic—neurohypophyseal system Renin—angiotensin system.

Subclinical thyroid dysfunction is relatively common in patients over 65 years of age. The Japanese-Brazilian thyroid study. Show more Show less. Iodine-induced hyper-thyroidism after contrast media. Dorland’s Illustrated Medical Dictionary.

Continuing navigation will be considered as acceptance of this use. Larry Jameson, Anthony s. Universidad Tecnolica de Pereira.

Wolff-Chaikoff Effect vs. Jod-Basedow Phenomenon | Medicine Specifics

Effect of iodinated contrast media on thyroid function in adults. The Jod-Basedow effect typically occurs jor comparatively small increases in iodine intake, in people who have thyroid abnormalities that cause the gland to function without the control of the pituitary i.


Universidad Tecnolica de Pereira, Risaralda. Br J Radiol ;54 Thyroid hormones have a significant impact on heart function, mediated by genomic and non-genomic effects.

Previous article Next article. Thyroid hormones upregulate the expression of the sarcoplasmic reticulum calcium-activated ATPase and downregulate the expression of phospholamban.

Blood sugar regulation Calcium metabolism. November – December Pages Physiology of the endocrine system.

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SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal’s impact. In both instances, the underlying cause is the high concentration of iodine in this medication.

In individuals with a normal baasedow, the gland eventually escapes from this inhibitory jkd and iod organification resumes; however, in patients with underlying autoimmune thyroid disease, the suppressive action of high iodide may persist.

By using this site, you agree to the Terms of Use and Privacy Policy. Hyperthyroid subjects given iodide may experience a decrease in basal metabolic rate that is comparable to that seen after thyroidectomy. Abstract Exposure to excessive amounts of iodine blocks the activity of the enzyme thyroid peroxidase TPOa phenomenon known as Wolf-Chaikoff effect.