LEI 11488 PDF

Leiurotoxin I (Lei-NH2), a toxin isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, is a Biochemistry 41 (38), ISIN Code, Issuer Name, Security Type, FX, Term. XS · Weinberg Capital DAC, CP, EUR, 7d. XS · Banco Safra SA, CD, USD, 2y d. Anping Lei at Shenzhen University . Lei et al; licensee BioMed Central Ltd . This is an Open Access article

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The primary mechanism for up-regulation of the HO-1 gene is by increasing transcription of this gene [ 1920 ]. Biochem Biophys Res Commun. Homocysteine induces heme oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cell.

Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells. Back to tab navigation Download options Please wait Representative results of three independent experiments are shown.

The ldi changes of HHcy-induced liver injuries include chronic inflammation, fibrosis, cirrhosis, and so on. The inhibitor was named leiurotoxin I, represents less than 0. Consequently, Nrf2 itself li activated and increase HO-1 transcription to defense oxidative stress. Proteins concentrations were determined by the BCA assay Pierce.

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Besides, SOD enzyme activities were impaired and the level of oxidative stress markers, such as ldi MDA were elevated in the liver from mice supplemented with methionine compared with control mice. Amine-containing compounds including polymers, oligomers and small molecules, without conventional fluorophores, are found to emit strong visible fluorescence after a one-step heat treatment. This article has been cited by other articles in PMC. Otherwise, HO-1 knockout mice developed major hemosiderosis and chronic inflammatory in liver, suggesting HO-1 induction as an important cellular endeavor for hepatoprotection [ 1718 ].


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Uncovering a broad class of fluorescent amine-containing compounds by heat treatment. Hyperhomocysteinemia HHcy is an independent risk factor lel liver diseases, such as fatty liver and hepatic fibrosis [ 5 ]. Hyperhomocysteinemia HHcy is an independent risk factor for liver diseases, such as fatty liver and hepatic fibrosis.

Herrmann W, Knapp JP. The livers were blotted dry and weighed and then homogenized in 8 volumes of lysis buffer pH7. Homocysteine and cardiovascular disease in diabetes mellitus. The role of heme oxygenase-1 in pulmonary disease. Clin Chem Lab Med. Protein is formed by a helix and a double-stranded beta-sheet and stabilized by three disulfide bridges 4.

The PCR conditions were as follows: However, the mechanisms underlying this pro-oxidative effect of homocysteine Hcy in hepatocytes remain largely unknown.

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Reproduced material should be attributed as follows: The synthetic peptides were tested in vitro for their capacity to compete with the binding 1148 [ I] apamin to rat brain synaptosomes and in vivo for their neurotoxicity in mice.

Jump to main content. Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. Representative images of three independent experiments were shown.

Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes

Journal of Peptide Research. These results suggested that Hcy accumulation has a promoting effect on oxidative stress, which might be partially contributed by the decrease of anti-oxidative enzyme HO Journal List Nutr Metab Lond v. Thus, it is fold less potent pei apamin. Back to tab navigation Fetching data from CrossRef.

A proton NMR study at MHz of leiurotoxin I in water was initially carried out to elucidate the secondary structure of toxin. In the current study, we demonstrated that Nrf2 as well as Bach1 are involved in the downregulation of HO-1 leii expression by Hcy.


If you are the author ldi this article lfi do not need to formally request permission to reproduce figures, diagrams etc. Alam J, Cook 11488. Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation.

Phosphorylation of tyrosine controls nuclear export of Nrf2. In the nucleus, Bach1 can form heterodimers with the Maf-related protein family [ 44 ], and then leads to switching off Nrf2 and suppression of 11848 gene expression to basal levels through competition with Nrf2 for binding to ARE [ 37 ].

However, Hcy had no effect on the gene expression of Nrf2, the major transcriptional regulator of HO The cytosolic and nuclear proteins were extracted separately after Hcy treatment and subjected to Western blotting assay. We weighed the mice every week and calculated the consumption of water and food for each group. Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Hcy accumulation resulted in oxidative stress and HO-1 downregulation.

C Protein levels of HO-1 were analyzed using Western blotting. The online version of this article doi: Homocyst e ine and arterial occlusive diseases.